Concepedia

Distinct Functional Roles for the Menkes and Wilson Copper Translocating P-type ATPases in Human Placental Cells

B. Hardman, Agnes Michalczyk, Mark Greenough, James Camakaris, JJulian Mercer, M. Leigh Ackland

Cellular Physiology and Biochemistry · 2007 · 46 citations · 24 references

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Abstract

Overall, these results provide definitive evidence for distinct roles of MNK and WND in the human placenta, and are consistent with a role for MNK in the transport of copper into the fetal circulation, and through delivery of copper to placental cuproenzymes, whilst WND contributes to the maintenance of placental copper homeostasis by transporting copper to the maternal circulation.

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