Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduced potency in vitro

GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage.

Michael S. McGrath, Keumrock Hwang, Shannon Caldwell et al. · Proceedings of the National Academy of Sciences · 1989 · 303 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

Nandini V. Katre, M J Knauf, W Laird · Proceedings of the National Academy of Sciences · 1987 · 245 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +15

A new procedure for the synthesis of polyethylene glycol-protein adducts; Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and α2-macroglobulin

Charles Beauchamp, Steven L. Gonias, David P. Menapace et al. · Analytical Biochemistry · 1983 · 207 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

A phase I/II study of trichosanthin treatment of HIV disease

Vera S. Byers, Alan S. Levin, Larry A. Waites et al. · AIDS · 1990 · 118 citations

Medicine, Infectious Diseases, Pharmacology +17

Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation

Xian‐Hui He, Pang‐Chui Shaw · Life Sciences · 1999 · 93 citations

Life Sciences, Biochemistry, Biotechnology +7