A noval iodine-induced sequential cyclization reaction of norbornene derivatives leading to the formation of novel iodo-cage compounds

Abstract

Teatment of the bis-endo-thioester and acyl group substituted norbornenes 1a–d and 9a–c with iodine in aqueous tetrahydrofuran at 25 °C gave the noval iodo-cage compounds 2a–d and 10a–c in 80–90% yields respectively, the first example of sequential cyclization of norbornene derivatives induced by an iodine electrophile.