Isolation and Characterization of a Mutant Mouse Lymphoma Cell Sensitive to Methyl Methanesulfonate and X Rays

Koki Sato, Naoko Hieda

Radiation Research · 1979 · 92 citations · 19 references

Concepts

Abstract

A methyl methanesulfonate-sensitive strain has been isolated from L5178Y mouse lymphoma cells. This mutant, M10, is more sensitive to killing by X rays than the parent wild-type strain. This sensitivity to the alkylating agent and ionizing radiation has not changed for 11 months since the isolation of the mutant. The plating efficiency, doubling time, and sensitivity to ultraviolet light of M10 cells are not appreciably different from those of the wild-type cells.

References

19