Cholinesterase Reactivation in Vivo with a Novel Bis-Oxime Optimized by Computer-Aided Design

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +17

A powerful reactivator of alkylphosphate-inhibited acetylcholinesterase

Irwin B. Wilson, S. Ginsburg · Biochimica et Biophysica Acta · 1955 · 515 citations

Life Sciences, Biochemistry, Pharmacology +14

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

Zoran Radić, Natilie A. Pickering, Daniel C. Vellom et al. · Biochemistry · 1993 · 439 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

Yuan‐Ping Pang, Polly A. Quiram, Tanya M. Jelacic et al. · Journal of Biological Chemistry · 1996 · 346 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17