The enantiocontrolled synthesis of (–)-tricholomenyn A, a novel antimitotic enynylcyclohexenone from Tricholoma acerbum

Abstract

(–)-Tricholomenyn A, a structurally novel antimitotic enynylcyclohexenone from Tricholoma acerbum, is synthesized in an enantiocontrolled manner from a chiral synthon of cis-1,4-dihydroxycyclohexa-2,5-diene and verifies the relative and the absolute structures of the natural product.