Structure of Sch 419560, a Novel .ALPHA.-Pyrone Antibiotic Produced by Pseudomonas fluorescens.

Abstract

Rapid increase of resistance to antibacterial agents in recent years has become a major global public health problem.1,2) The development of antibiotics with novel mechanisms of action is one of the most important measures leading to the control of bacterial infectious diseases in the new millennium. The genomic antibacterial approach plays a critical role in the discovery of new targets by searching for genes essential to the growth of bacteria.