Efficient synthesis of sitagliptin phosphate, a novel DPP-IV inhibitor, via a chiral aziridine intermediate

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff et al. · Science · 2010 · 1.7K citations

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(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dooseop Kim, Liping Wang, Maria Beconi et al. · Journal of Medicinal Chemistry · 2004 · 817 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

Expert Opinion on Investigational Drugs · 2003 · 208 citations

Medicine, Endocrinology, Pharmacology +17

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

Daniel J. Drucker · Expert Opinion on Investigational Drugs · 2003 · 204 citations

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First Generation Process for the Preparation of the DPP-IV Inhibitor Sitagliptin

Karl B. Hansen, Jaume Balsells, Spencer D. Dreher et al. · Organic Process Research & Development · 2005 · 162 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10