Concepedia

Identification of the ferroxidase centre in ferritin

David M. Lawson, Amyra Treffry, Peter J. Artymiuk, Pauline M. Harrison, S J Yewdall, Alessandra Luzzago, Gianne Cesareni, Sonia Levi, Paolo Arosio

FEBS Letters · 1989 · 311 citations · 12 references

DOI

Concepts

Abstract

Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

References

12

Ferritin: design and formation of an iron-storage molecule

Geoffrey C. Ford, P. M. Harrison, David W. Rice et al. · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1984 · 566 citations

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On ferritin heterogeneity. Further evidence for heteropolymers.

Paolo Arosio, T.G. Adelman, J Drysdale · Journal of Biological Chemistry · 1978 · 464 citations · Full text

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Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and of two H-chain deletion mutants.

Sonia Levi, Alessandra Luzzago, Gianni Cesareni et al. · Journal of Biological Chemistry · 1988 · 377 citations · Full text

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The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake

Ian G. Macara, T. G. Hoy, Pauline M. Harrison · Biochemical Journal · 1972 · 245 citations · Full text

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The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification

C. F. A. Bryce, Robert R. Crichton · Biochemical Journal · 1973 · 112 citations · Full text

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