Mutations Affecting G-Protein Subunit α₁₁in Hypercalcemia and Hypocalcemia

Abstract

Gα11 mutants with loss of function cause familial hypocalciuric hypercalcemia type 2, and Gα11 mutants with gain of function cause a clinical disorder designated as autosomal dominant hypocalcemia type 2. (Funded by the United Kingdom Medical Research Council and others.).