Chemical Communications · 2003 · 49 citations · 15 references
Molecular BiologyNucleic Acid Amplification TestGuanine BaseNucleic Acid ChemistryNaked EyePhotophysical PropertyMolecular SpectroscopyBiophysicsGuanine–adenine TransitionBiochemistryOligonucleotideDna ReplicationSmall CompoundSingle-molecule DetectionStructural BiologyNatural SciencesGuanine-adenine TransitionHydrogen BondNucleic Acid AmplificationChemical ProbeMedicine
In combination with abasic site-containing oligodeoxynucleotides, 2-amino-4-oxopteridine (pterin) can selectively recognize guanine base over other nucleobases accompanied by fluorescence quenching, which allows clear detection of a guanine-adenine transition with the naked eye.
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