Respiration · 2009 · 28 citations · 0 references
PharmacyPharmacologyToxicologyDrug DeliveryPulmonary Drug DeliveryPulmonary Function TestingInhalation Dosage FormsInhalation Drug DeliveryPulmonary ToxicologySurfactantsVolatile Organic CompoundsLung ComplianceLung Compliance MonitoringNatural SurfactantsPulmonary Surfactant PhysiologySurface PressureSurface Tension MeasurementSurfactant EffectsSurfactant Formulation
Volatile aromatics, eucalyptol, eucalyptus oil, camphor and menthol were spread on synthetic DPL films and pulmonary surfactants; the initial surface pressure of the surfactants was measured and the additional surface pressure increment recorded. Eucalyptol was allowed to be inhaled by rabbits and lung compliance was monitored. Under our experimental conditions the volatile aromatics exhibited surfactant-like effects, namely a decrease in surface tension between water and air and thus improved lung compliance values in vivo.