Facile Preparation of PtII-Nucleobase Monoadducts with trans Geometry: Structural Characterization and Kinetics for Cl− Hydrolysis Reactions of trans-[PtCl(NH3)2(L-N7)]n+ (L=9-Methyladenine or 9-Methylhypoxanthine)

Abstract

PtII-nucleobase complexes of the type trans-[PtCl(NH3)2(L-N7)]n+ are prepared by an efficient procedure. Kinetics for the Cl− hydrolysis studied by 195Pt NMR and HPLC analysis show that in basic aqueous solution the incoming water molecule displaces the Cl− ligand more readily in the depicted monocationic 9-methyladenine complex (1) than in the neutral 9-methylhypoxanthine complex (2).