Proceedings of the National Academy of Sciences · 1964 · 25 citations · 0 references
Life SciencesBiochemistryBiologyMolecular BiophysicsProtein TranslationStructural BiochemistryRibosome FunctionRibosome StructureTranslation ElongationRibosomal Conformational ChangesRibosomal Conformational DynamicsRibosomal TranslocationRibosome Conformational DynamicsRibosome Rotational StatesRotationsSpatial RotationsTranslation Kinetics
The ribosome is a macromolecular machine that undergoes global conformational rearrangements during translation, that involve coupled movements of ribosomal subunits, tRNAs, and the L1 stalk. However, there is a disagreement between different ...The two main steps of translation, peptidyl transfer, and translocation are accompanied by counterclockwise and clockwise rotations of the large and small ribosomal subunits with respect to each other. Upon peptidyl transfer, the small ribosomal subunit ...