Organic Letters · 2008 · 37 citations · 31 references
PharmacyMedicinal ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisOrganic SynthesisRetrosynthetic AnalysisAlkyne Cobalt ComplexesAsymmetric SynthesisEnantioselective SynthesisNatural Product Total Synthesis
The synthesis of a protected dephosphofostriecin, and thereby a formal synthesis of fostriecin, has been accomplished. Two of the four chiral centers are controlled by an external chiral auxiliary and the other two are synthesized stereoselectively, one by a novel 1,4-asymmetric induction using cobalt-alkyne complex, and the other by 1,3-asymmetric induction.
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