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INHIBITION OF FERTILITY IN MICE BY STEROID IMPLANTS
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1965
Year
SpermatogenesisHormonal ContraceptiveFertilityReproductive HealthGynecologyFemale Reproductive FunctionReproductive BiologyOvarian AgingReproductive EndocrinologyBasic Progestational ActivityFemale InfertilityReproductive MedicinePublic HealthInfertilitySteroid ImplantsAbstract InhibitionEndocrinologyPharmacologyHuman ReproductionUterine ReceptivityMedicineEndocrine ResearchReproductive Hormone
ABSTRACT Inhibition of fertility in female mice by steroid implants has been studied. 19-Norprogesterone, 10% and 20 % pellets, and testosterone, 15% and 45 % pellets, were effective fertility inhibitors in female mice. Two important antifertility steroids, chlormadinone and 17α-acetoxypregn-4,6-diene-3,20-dione were only moderately effective. The present data on a relatively limited number of compounds indicate that the anti-fertility activity of progestational agents in normal female mice is a parameter independent of the basic progestational activity, anti-ovulatory activity and anti-oestrogenic activity.