European Journal of Endocrinology · 1965 · 10 citations · 0 references
MedicineEndocrinologyPharmacologyFertilityReproductive EndocrinologyReproductive PhysiologyGonadal Steroid HormonesHormonal ContraceptionOvarian FunctionReproductive PharmacologyRodent ReproductionRodent Reproductive MedicineAntifertility AgentsFertility PharmacologyFertility SuppressionHormonal Contraceptive TherapyOvulatory MechanismsReproductive Drug PharmacologyReproductive Endocrine PharmacologySex Steroid Pharmacology
ABSTRACT Inhibition of fertility in female mice by steroid implants has been studied. 19-Norprogesterone, 10% and 20 % pellets, and testosterone, 15% and 45 % pellets, were effective fertility inhibitors in female mice. Two important antifertility steroids, chlormadinone and 17α-acetoxypregn-4,6-diene-3,20-dione were only moderately effective. The present data on a relatively limited number of compounds indicate that the anti-fertility activity of progestational agents in normal female mice is a parameter independent of the basic progestational activity, anti-ovulatory activity and anti-oestrogenic activity.