Experimental radiation therapy of tumors with I-131-carrying antibodies to fibrin.

Abstract

Antibody to rat fibrin, prepared from immunized rabbits and made radioactive by in vitro coupling with I131, localized with considerable specificity in several transplantable rat tumors after intravenous injection into rats bearing these tumors. Intravenous doses of 1.22–4.13 mc. of I131 attached to rat fibrin antibody, injected into rats bearing the transplantable Murphy-Sturm lymphosarcoma after the tumors had grown to 2–3 gm. in weight, consistently resulted in rapid and permanent regression of these tumors.