BMJ · 1983 · 265 citations · 20 references
MedicineCardiologyPharmacotherapyHuman NutritionMicronutrient NutritionMineral MetabolismBlood Pressure ManagementDiuretic TherapyHypertension ManagementMagnesium HomeostasisMagnesium NutritionMineral SupplementationBlood PressureBlood Pressure PharmacodynamicsBody Weight RegulationCongestive Heart Failure ManagementElectrolytesMagnesium BalanceMagnesium Repletion TherapyUrine Electrolytes
Twenty patients receiving long term diuretic treatment for arterial hypertension (18 patients) or congestive heart failure (two patients) received magnesium supplementation as aspartate hydrochloride 15 mmol/day for six months. Both systolic and diastolic pressures decreased significantly, by a mean of 12/8 mm Hg. No significant changes were recorded in plasma or urinary electrolytes except for magnesium, 24 hour urinary volumes, or body weight after treatment. The effect of magnesium on blood pressure may be direct or through influences on the internal balance of potassium, sodium, and calcium.
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MODERATE POTASSIUM SUPPLEMENTATION IN ESSENTIAL HYPERTENSION
GrahamA. Macgregor, NirmalaD. Markandu, S J Smith et al. · The Lancet · 1982 · 253 citations
HYPERTENSION EXPLAINED BY STARLING'S THEORY OF CIRCULATORY HOMŒOSTASIS
J.G.G. Borst · The Lancet · 1963 · 218 citations
HYPERTENSION EXPLAINED BY STARLING'S THEORY OF CIRCULATORY HOMŒOSTASIS
Jannie Borst, Alida Borst-de Geus · The Lancet · 1963 · 204 citations
Magnesium Deficiency in Patients on Long-Term Diuretic Therapy for Heart Failure
Edward Jacob · BMJ · 1972 · 177 citations · Full text