Concepedia

Tumor Necrosis Factor-.ALPHA. Downregulates the Voltage Gated Outward K+ Current in Cultured Neonatal Rat Cardiomyocytes A Possible Cause of Electrical Remodeling in Diseased Hearts

Hideaki Kawada, Shinichi Niwano, Hiroe Niwano, Yoshihiro Yumoto, Yuko Wakisaka, Masaru Yuge, Katsumasa Kawahara, Tohru Izumi

Circulation Journal · 2006 · 66 citations · 24 references

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Abstract

Treatment with TNF-alpha induced reductions in Ito as well as cellular hypertrophy in neonatal cultured myocytes, which indicates that TNF-alpha might play a role in promoting electrical remodeling of cardiomyocytes under inflammatory conditions.

References

24

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Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

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Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes

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Involvement of Reactive Oxygen Species-mediated NF- κ B Activation in TNF- α -induced Cardiomyocyte Hypertrophy

Yoshiharu Higuchi, Kinya Otsu, Kazuhiko Nishida et al. · Journal of Molecular and Cellular Cardiology · 2002 · 194 citations

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Impairment of HERG K+ Channel Function by Tumor Necrosis Factor-α

Jingxiong Wang, Huizhen Wang, Yiqiang Zhang et al. · Journal of Biological Chemistry · 2004 · 143 citations · Full text