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Tilorone Hydrochloride: An Orally Active Antiviral Agent
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1970
Year
Medicinal ChemistryLeast NineAntiparasitic AgentMedicineDna GroupsNatural SciencesAntiviral Drug DevelopmentMolecular BiologyVirologyTilorone HydrochloridePharmacotherapyAntiviral DrugPharmacologyAntiviral CompoundDrug DiscoveryDrug Resistance
Tilorone hydrochloride, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride, given orally to mice before they are infected is active against at least nine viruses of both RNA and DNA groups. The compound is effective when given prophylactically; the optimum time of treatment depends on the route of infection.