Journal of the American Chemical Society · 2005 · 279 citations · 23 references
Inorganic ChemistryEngineeringBiochemistryPrime Reaction IntermediateBioactive MetalCoordination ComplexAlbumin-conjugated Manganese CorrolesMolecular ComplexCatalysisMetal ComplexesChemistryRedox ChemistryMedicineRedox BiologyDeoxygenationElectrochemistryOxidative Stress
An extremely simple biomimetic oxidation system, consisting of mixing metal complexes of amphiphilic corroles with serum albumins, utilizes hydrogen peroxide for asymmetric sulfoxidation in up to 74% ee. The albumin-conjugated manganese corroles also display catalase-like activity, and mechanistic evidence points toward oxidant-coordinated manganese(III) as the prime reaction intermediate.
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