Journal of the American Chemical Society · 2005 · 279 citations · 23 references
Natural SciencesBiochemistryChemistryBiocatalysisInorganic ChemistryRedox BiochemistryBiocatalytic OxidationBioinorganic ChemistryChemical OxidationCoordination ChemistryReactive Oxygen SpeciesBiomimetic OxidationComplexation ChemistryManganese ChemistryManganese Oxidation StateManganese Redox ChemistryMetal-catalyzed OxidationMetals-catalyzed OxidationRedox-active Metal Complexes
An extremely simple biomimetic oxidation system, consisting of mixing metal complexes of amphiphilic corroles with serum albumins, utilizes hydrogen peroxide for asymmetric sulfoxidation in up to 74% ee. The albumin-conjugated manganese corroles also display catalase-like activity, and mechanistic evidence points toward oxidant-coordinated manganese(III) as the prime reaction intermediate.
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