Synthesis, Antibacterial and Antifungal Activity of Some Novel 3,5‐Disubstituted‐1<i>H</i>‐1,2,4‐triazoles

Abstract

A rapid and efficient one-pot condensation reaction of long-chain alkyl and alkenyl acid hydrazides and nitriles was carried out to afford 3,5-disubstituted-1H-1,2,4-triazoles. The compounds 5a-o were screened for in-vitro antibacterial activity against the representative panel of two Gram-positive and two Gram-negative bacteria. All the synthesized compounds were also tested for their inhibitory action against five strains of fungi. The various compounds show potent inhibitory action against test organisms. The compounds 5a-o were characterized on the basis of elemental analysis and spectral data.