Journal of Medicinal Chemistry · 1977 · 85 citations · 0 references
Life SciencesMedicinal ChemistryPharmacologyMolecular PharmacologyMolecular VirologyVirologyAntiviral AgentsAntiviral PharmacologyDna Virus BiologyEnzyme InhibitionAntiviral Drug MechanismsAntiviral Mechanisms Of ActionAntiviral Natural ProductsAntiviral Structure-activity RelationshipsAntiviral TherapeuticsDirect-acting AntiviralsViral Replication Inhibitors
The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.