Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Pirenzepine distinguishes between different subclasses of muscarinic receptors

Rudolf Hammer, Christopher P. Berrie, N.J.M. Birdsall et al. · Nature · 1980 · 1.3K citations

Medicine, Neuroscience, Pharmacology +16

Antagonist binding profiles of five cloned human muscarinic receptor subtypes.

Frank Dörje, J. Wess, G. Lambrecht et al. · Journal of Pharmacology and Experimental Therapeutics · 1990 · 612 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

A COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE‐SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA‐PIG ATRIAL PACEMAKER CELLS AT 29°C AND IN ILEUM AT 29°C AND 37°C

R. B. BARLOW, K.J. BERRY, Patricia A. Glenton et al. · British Journal of Pharmacology · 1976 · 292 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist

Antonio Giachetti, R. Micheletti, E. Montagna · Life Sciences · 1986 · 283 citations

Medicine, Cardiology, Pharmacology +15