Glycerol Effects on the Perilymphatic and Cerebro-Spinal Fluid Pressure

Abstract

Glycerol has been injected intravenously in guinea pig and its effects on the pressure in the cochlear fluids have been studied. Simultaneously, arterial and cerebro-spinal pressures have been recorded. Glycerol lowered the intracochlear as well as cerebro-spinal and blood pressures, the latter only temporarily. Different possible mechanisms for the glycerol effect on the intracochlear pressure and its transient effect on hearing in Meniere's disease are discussed.