Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Genetics, Molecular Biology, Hif-1 Subunits +21

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Hui-Qiao Tian, Steven L. McKnight, David W. Russell · Genes & Development · 1997 · 1.3K citations · Full text

Transcriptional Regulation, Systems Biology, Developmental Biology +15

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1  in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

Hif Prolyl-hydroxylase 2, Key Oxygen Sensor, Biochemistry +9

Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling

Ju‐Seog Lee, In‐Sun Chu, Jeonghoon Heo et al. · Hepatology · 2004 · 913 citations · Full text

Engineering, Pathology, Gene Expression Profiling +18

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

GL Semenza · Blood · 1993 · 743 citations · Full text