In Vitro and In Vivo Uptake Study of<i>Escherichia coli</i>Nissle 1917 Bacterial Ghosts: Cell-Based Delivery System to Target Ocular Surface Diseases

Abstract

The findings that EcN BGs are nontoxic and effectively internalized in vitro by human and in vivo by guinea pig conjunctival cells comprise an important contribution to the future use of BGs as a system for conjunctival delivery of drugs and vaccines, either to treat or prevent ocular surface diseases.