Increased hemostasis potential persists in women with previous thromboembolism with or without APC resistance

Mutation in blood coagulation factor V associated with resistance to activated protein C

Rogier M. Bertina, Bobby P. C. Koeleman, Ted Koster et al. · Nature · 1994 · 3.8K citations

Medicine, Genetics, Hematology +14

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

Björn Dahlbäck, Martin Carlsson, Peter J. Svensson · Proceedings of the National Academy of Sciences · 1993 · 2K citations

Medicine, Hematology, Clinical Biochemistry +15

Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men

Paul M. Ridker, Charles H. Hennekens, Klaus Lindpaintner et al. · New England Journal of Medicine · 1995 · 1.1K citations · Full text

Medicine, Genetics, Molecular Genetics +17

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

FR Rosendaal, Ted Koster, PH Reitsma · Blood · 1995 · 1K citations

Medicine, Genetics, Hematology +16

A Reduced Sensitivity for Activated Protein C in the Absence of Factor V Leiden Increases the Risk of Venous Thrombosis

Marieke C. Visser, Frits R. Rosendaal, Rogier M. Bertina · Blood · 1999 · 312 citations

Medicine, Genetics, Molecular Biology +17