Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

Helmut O. Steinberg, Ginger Brechtel, Andi Johnson et al. · Journal of Clinical Investigation · 1994 · 1.2K citations · Full text

Hypertension, Nitric Oxide Release, Insulin Signaling +22

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

Jonathan Backer, Martin G. Myers, Steven E. Shoelson et al. · The EMBO Journal · 1992 · 1K citations · Full text

Molecular Pharmacology, Insulin Signaling, Molecular Physiology +14

Structural basis for the binding of proline-rich peptides to SH3 domains

Hongtao Yu, James Chen, Sibo Feng et al. · Cell · 1994 · 1K citations

Protein Assembly, Biochemistry, Protein Folding +9

Roles for Insulin Receptor, PI3-Kinase, and <i>Akt</i> in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

Guangyuan Zeng, Frederick H. Nystrom, Lingamanaidu V. Ravichandran et al. · Circulation · 2000 · 741 citations

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

Gu‐Qing Zeng, Michael J. Quon · Journal of Clinical Investigation · 1996 · 729 citations · Full text

Hypertension, Nitric Oxide, Tyrosine Kinase +18