Concepedia

Precipitation in the small intestine may play a more important role in the in vivo performance of poorly soluble weak bases in the fasted state: Case example nelfinavir

Yasushi Shono, Ekarat Jantratid, Jennifer Dressman

European Journal of Pharmaceutics and Biopharmaceutics · 2011 · 89 citations · 23 references

DOI

Concepts

References

23

Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs

Eric Galia, Eleftheria Nicolaides, D. Hörter et al. · Pharmaceutical Research · 1998 · 915 citations

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

Ekarat Jantratid, Niels Janssen, Christos Reppas et al. · Pharmaceutical Research · 2008 · 734 citations

, , +4

Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies

Lida Kalantzi, Konstantinos Goumas, V. Kalioras et al. · Pharmaceutical Research · 2005 · 647 citations

, , +7

Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds

Maria Vertzoni, Jennifer Dressman, John M. Butler et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2005 · 350 citations

, , +9

Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine

Edmund Kostewicz, Martin Wunderlich, Ulrich Brauns et al. · Journal of Pharmacy and Pharmacology · 2004 · 312 citations