Cystic fibrosis transmembrane conductance regulator (<i>CFTR</i>) gene mutations and risk for pancreatic adenocarcinoma

Abstract

Carrying a disease-associated mutation in CFTR is associated with a modest increase in risk for pancreatic cancer. Those affected appear to be diagnosed at a younger age, especially among smokers. Clinical evidence of antecedent pancreatitis was uncommon among both carriers and noncarriers of CFTR mutations.