Interactions between HIV rev and nuclear import and export factors: the rev nuclear localisation signal mediates specific binding to human importin-β

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

Michael H. Malim, Joachim Hauber, Shu‐Yun Le et al. · Nature · 1989 · 1.3K citations

Life Sciences, Molecular Biology, Molecular Genetics +17

Identification of a signal for rapid export of proteins from the nucleus

Wei Wen, Judy L Meinkotht, Roger Y. Tsien et al. · Cell · 1995 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

Utz Fischer, Jochen Huber, Wilbert C. Boelens et al. · Cell · 1995 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

Michael Rexach, Günter Blobel · Cell · 1995 · 766 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

Michael H. Malim, S Böhnlein, Joachim Hauber et al. · Cell · 1989 · 734 citations

Life Sciences, Biochemistry, Molecular Biology +14