Concepedia

Simultaneous quantification of carvedilol and its metabolites in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and pharmacokinetic application

Junwei Li, Li Wang, Shuanghu Wang, Mengchun Chen, Er-min Gu, Guoxin Hu, Ren‐Shan Ge

Journal of Chromatography B · 2014 · 12 citations · 34 references

DOI

Concepts

References

34

In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.

Harriet G. Oldham, Stephen E. Clarke · PubMed · 1997 · 150 citations

, , +17

Stereoselective disposition of carvedilol is determined by CYP2D6*

Hong-Hao Zhou, Alastair J.J. Wood · Clinical Pharmacology & Therapeutics · 1995 · 132 citations

, , +15

Pharmacokinetics and disposition of carvedilol in humans.

G. Neugebauer, W. Akpan, E von Möllendorff et al. · PubMed · 1987 · 124 citations

, , +13

The pharmacokinetics of carvedilol and its metabolites after single and multiple dose oral administration in patients with hypertension and renal insufficiency

T. W. B. Gehr, David M. Tenero, D. A. Boyle et al. · European Journal of Clinical Pharmacology · 1999 · 113 citations

, , +13

Stereoselective disposition of carvedilol in man after intravenous and oral administration of the racemic compound

G. Neugebauer, W. Akpan, B. Kaufmann et al. · European Journal of Clinical Pharmacology · 1990 · 110 citations

, , +4