Rh‐Catalyzed Highly Enantioselective Synthesis of 3‐Arylbutanoic Acids

Abstract

It's in the mix: The reaction conditions—catalyst, additive, and solvent—have been optimized for the asymmetric hydrogenation of 3-aryl-3-butenoic acids. The rigid, chiral bisphospholane ligand (Sp,Rc)-DuanPhos is crucial to achieving high enantioselectivity.