Tumour necrosis factor-α enhances cAMP-induced programmed cell death in mouse thymocytes

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell, Lloyd J. Old, Robert Kassel et al. · Proceedings of the National Academy of Sciences · 1975 · 4.5K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +15

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

A H Wyllie, R. G. Morris, Alex Smith et al. · The Journal of Pathology · 1984 · 1.6K citations

Life Sciences, Cell Biology, Molecular Biology +16

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

C A Dinarello, Joseph G. Cannon, S. M. Wolff et al. · The Journal of Experimental Medicine · 1986 · 1.5K citations · Full text

Life Sciences, Immunology, Pharmacology +12

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

Christopher A. Smith, Gwyn T. Williams, Rosetta Kingston et al. · Nature · 1989 · 1.1K citations

Life Sciences, Cell Biology, Immunology +10

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

Scott M. Laster, John G. Wood, L R Gooding · The Journal of Immunology · 1988 · 910 citations · Full text

Veterinary Medicine, Cell Biology, Pathobiology +7