Concepedia

Inhibition of Human Trophoblast Invasiveness by High Glucose Concentrations

Louiza Belkacemi, Gendie E. Lash, Shannyn K. Macdonald-Goodfellow, Jason D. Caldwell, Charles H. Graham

The Journal of Clinical Endocrinology & Metabolism · 2005 · 51 citations · 36 references

DOIFull text

Open access

Abstract

These findings indicate that high glucose concentrations inhibit the invasiveness of HTR-8/SVneo cells by preventing uPA activation. Therefore, through its effects on uPA activity, glucose may be an important regulator of trophoblast invasiveness during implantation and placentation.

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