Factors Influencing the Cure of Salmonella Carriers

Abstract

Article1 December 1962Factors Influencing the Cure of Salmonella CarriersBAYARD S. TYNES, M.D., JOHN P. UTZ, M.D., F.A.C.P.BAYARD S. TYNES, M.D.Search for more papers by this author, JOHN P. UTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-871 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTyphoid Mary is known to physicians and lay public as well. Although the medical journal (1) estimate of 53 cases and 3 deaths attributable to her is far below the 1,300 victims claimed in a recent article in Pageant (2), the salmonella carrier problem is still with us. Furthermore, nearly all cases of typhoid these days are from carrier contacts.This paper describes the role of antibiotic treatment and cholecystectomy in the control of the salmonella carrier state and reviews the reasons for the occasional failure.HISTORYCredit for the earliest concept of the fecal spread of typhoid or enteric...References1. SOPER A: The work of a chronic typhoid germ distributor. JAMA XLVIII: 2019, 1907. CrossrefGoogle Scholar2. SUFRIN M: Her name was Typhoid Mary. Pageant 154, October, 1961. Google Scholar3. BUDD W: The fever at the Clergy Orphan Asylum. Lancet 2: 617, 1856. CrossrefGoogle Scholar4. BUDD W: Intestinal fever: its mode of propagation. Lancet 2: 694, 1856. CrossrefGoogle Scholar5. VOGELSANG TM: Typhoid and paratyphoid B carriers and their treatment: experiences from western Norway. Grieg, Bergen, 1950, 368 pp. Google Scholar6. GEZON HM: Salmonellosis. DM, July, 1959. Google Scholar7. GARBAT AL: Typhoid Carriers and Typhoid Immunity, Rockefeller Institute for Medical Research, Monograph No. 16, 1922. Google Scholar8. VOGELSANGBØE TMJ: Temporary and chronic carriers of Salmonella typhi and Salmonella paratyphi B. J. Hyg. (Lond.) 46: 252, 1948. CrossrefMedlineGoogle Scholar9. SAITO A: Studies on pathogenic microbes in bone marrow in typhoid and paratyphoid. Tohoku J. Exp. Med. 62: 183, 1955. CrossrefMedlineGoogle Scholar10. AMESROBBINS WRM: Age and sex as factors in the development of the typhoid carrier state, and a method for estimating carrier prevalence. Amer. J. Public Health 33: 221, 1943. CrossrefGoogle Scholar11. VOGELSANG TM: Occurrence of gallstones in post-mortem examinations of Bergen City Hospital. Med. Rev. (Bergen) 46: 1, 1929. Google Scholar12. MÅRTENSSON K: Studies on the etiology of gallstones. Acta Chir. Scand. supp. 62: 1, 1941. Google Scholar13. RAINSBARSONCRAWFORDSHREWSBURY AJGJNJF: A chemical and bacteriological study of gall stones: the presence of an actinomycete. Lancet 2: 614, 1960. CrossrefMedlineGoogle Scholar14. WHIPPLE AO: The surgical treatment of bile typhoid carriers. Ann. Surg. 90: 631, 1929. CrossrefMedlineGoogle Scholar15. FORSBECKHOLLON FCHC: Standards for determining the suitability of bile specimens for detection or release of typhoid carriers. Amer. J. Public Health 27: 253, 1937. CrossrefGoogle Scholar16. DEHLER : Zur Behandlung der Typhusbazillenträger. Muench. Med. Wschr. 54: 779 and 2134, 1907. Google Scholar17. HUMBERT R: Diagnostik und Therapie der Salmonellen-dauerausscheider. Deutsch. Med. Wschr. 84: 742, 1959. CrossrefMedlineGoogle Scholar18. STRETENBRINK A: Beiträge zur Pathologie und Therapie der Typhusbacillenträger; Kritische Susammenstellung über die Ergebnisse der medikamentösen Behandlung der Typhus und Paratyphus-bacillenstuhlausscheider. Ergebn. Inn. Med. Kinderheilk 33: 143, 1928. CrossrefGoogle Scholar19. KLOSEKNOTHESTAACK FHHH: Behandlungsversuche bei typhusbakterien Dauerausscheidern mit Penicillin. Aerztl. Wschr. 11: 489, 1956. Google Scholar20. MAIN RG: Treatment of the chronic alimentary enteric carrier. Brit. Med. J. 1: 328, 1961. CrossrefMedlineGoogle Scholar21. STREITFIELDSASLAWLAWSON MMMSRB: Chloramphenicol-tetracycline treatment of salmonellosis in children: strip gradient and replica strip gradient techniques as guides to therapy. J. Dis. Child. 94: 155, 1957. CrossrefMedlineGoogle Scholar22. EASTWOOD J: Oral humatin (paromomycin) in chronic enteric carriers. J. Hyg. (Lond.) 59: 65, 1961. CrossrefMedlineGoogle Scholar23. DAVIES FG: Clinical evaluation of the new antibiotic: kanamycin. Ann. N. Y. Acad. Sci. 76: 129, 1958. CrossrefMedlineGoogle Scholar24. STEWARTCOLESNIXONHOLT GTHMHHRJ: "Penbritin": an oral penicillin with broad-spectrum activity. Brit. Med. J. 2: 200, 1961. CrossrefMedlineGoogle Scholar25. RABE EF: The treatment of salmonellosis with massive doses of penicillin compared with other methods of therapy. Pediatrics 16: 590, 1955. MedlineGoogle Scholar26. BASSLERPETERS AAG: Hepatic calculi. Amer. J. Med. Sci. 214: 422, 1947. CrossrefMedlineGoogle Scholar27. GOODPASTURE EW: Concerning the pathogenesis of typhoid fever. Amer. J. Path. 13: 175, 1937. MedlineGoogle Scholar28. MCDERMOTT W: Microbial persistence. Yale J. Biol. Med. 30: 257, 1958. MedlineGoogle Scholar29. SHOWACREHOPPSDUBUYSMADEL JLHEHGJE: Effect of antibiotics on intracellular Salmonella typhosa. I. Demonstration by phase microscopy of prompt inhibition of intracellular multiplication. J. Immunol. 87: 153, 1961. Google Scholar30. HOPPSSMADELBERNHEIMDANAUSKASJACKSON HEJEBCJXEB: Effect of antibiotics on intracellular Salmonella typhosa. II. Elimination of infection by prolonged treatment. J. Immunol. 87: 162, 1961. MedlineGoogle Scholar31. PULASKIFUSILLO EJMH: Gallbladder bile concentrations of the major antibiotics following intravenous administration. Surg. Gynec. Obstet. 100: 571, 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda 14, Maryland.Requests for reprints should be addressed to John P. Utz, M.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 14, Maryland. 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WOODWARD, M.D., F.A.C.P., JOSEPH E. SMADEL, M.D.Therapy of Acute Bacterial Gastroenteritis 1 December 1962Volume 57, Issue 6Page: 871-882KeywordsAntibioticsBileChloramphenicolClinical laboratoriesInfectious diseasesMedical servicesPenicillinResearch laboratoriesSalmonellaTyphoid Issue Published: 1 December 1962 CopyrightCopyright ©, 1962, by The American College of PhysiciansPDF DownloadLoading ...