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Inhibitory Effect of N-Phenyl-N′-Aryl or Alkylthiourea Derivatives on Poliovirus Multiplication in Cell Cultures
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1972
Year
Antimicrobial ChemotherapyAntiviral DrugVirus YieldDrug ResistanceMedicinal ChemistryPoliovirus 1Antiviral Drug DevelopmentScreening Gradient-plaque-inhibiting TestPoliovirus MultiplicationBiochemistryVirologyPharmacologyAntiviral CompoundBiomolecular EngineeringAlkylthiourea DerivativesNatural SciencesAntiviral TherapyInhibitory EffectMedicineDrug Discovery
A study was made of antiviral activities in vitro of 54 derivatives of N-phenyl-N′-aryl or alkylthiourea with a basic structural formula C6H5NHCSNHR against poliovirus 1 (Mahoney). Eleven active compounds were selected by the Screening gradient-plaque-inhibiting test, some of which (N-phenyl-N′-4-carboxy-5-hydroxyphenylthiourea, N-phenyl-N′-3-hydroxyphenylthiourea) in a one-step growth cycle inhibit 99.4–99.9% of the virus yield. It was noted that, along with the -HN-CS-NH- group, the presence and spatial location of the hydroxyl group in the aryl or alkyl radical at N′-atom is of importance to antiviral activity.