Integrated Cellular Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma Patients

Comparison of four basic models of indirect pharmacodynamic responses

Natalie Dayneka, Varun Garg, William J. Jusko · Journal of Pharmacokinetics and Biopharmaceutics · 1993 · 811 citations

Medicine, Pharmacokinetics, Pharmacology +14

A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women

Pirow Bekker, Donna Holloway, Amy S Rasmussen et al. · Journal of Bone and Mineral Research · 2004 · 767 citations · Full text

Pharmacy, Clinical Sciences, Pharmacotherapy +17

General Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition

Donald E. Mager, William J. Jusko · Journal of Pharmacokinetics and Pharmacodynamics · 2001 · 587 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer.

Jean-Jacques Body, Thierry Façon, Robert E. Coleman et al. · Clinical Cancer Research · 2006 · 491 citations · Full text

Medicine, Oncology, Pharmacology +17

Modeling the interactions between osteoblast and osteoclast activities in bone remodeling

Vincent Lemaire, Frank Tobin, Larry D. Greller et al. · Journal of Theoretical Biology · 2004 · 451 citations

Medicine, Bioengineering, Biological Systems Modeling +13