Clinical Chemistry and Laboratory Medicine (CCLM) · 1978 · 23 citations · 12 references
Life SciencesBiochemistryBiomedical OpticsClinical BiochemistryNeuroimmunologyCerebrospinal Fluid BiomarkersFluid AnalysisPlasma ProteinsAlpha-2 Globulin AnalysisCerebrospinal Fluid AnalysisCerebrospinal Fluid DiagnosisCerebrospinal Fluid DiagnosticsCerebrospinal Fluid MarkersCerebrospinal Fluid Protein StudiesSerum Protein Biomarkers
The Laser-nephelometric technique is characterized by its easy handling, accuracy, good reproducibility and especially by the short time in which reliable results are available. A very good correlation was found between the results obtained by the electroimmunoassay and those obtained by Laser-nephelometry. In both techniques alpha2-macroglobulin is the largest serum protein that can be determined in normal unconcentrated cerebrospinal fluid (CSF). This is of diagnostic significance, since the serum/CSF ratios of both albumin and alpha2-macroglobulin are used as a parameter for the blood-CSF barrier condition.
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