Effect of Menstruation on Schoolgirls' Weekly Work

Abstract

ORAa long time, even though the gut was washed repeatedly with fresh Tyrode solution.The contraction caused by 1 ml. of C.D. could be antagonized completely by mepyramine maleate (0.02 y/ml. in the bath).We have thus obtained some evidence that our C.D. contained a histamine liberator, and we should like to advance the hypothesis that some of the symptoms of byssinosis are caused by a histamine liberator in the cotton dust inhaled by card-room workers.Our evidence indicates that the histamine release can take place without a preceding antigen-antibody reaction. SummaryInhalation of an extract of cotton dust caused a delay in the clearance of nitrogen from the lungs during oxygen-breathing.This effect, which presumably is due to bronchial obstruction, was obtained in two men who had not previously been exposed to the dust in cotton-mills.The effect was not caused by histamine present in the extract.The results of our experiments, as well as some of the symptoms of byssinosis, may be explained by the assumption that the cotton dust contains a histamine liberator.Some evidence was obtained, from animal prepara- tions, that the cotton-dust extract used here contained a substance capable of releasing histamine.This exceedingly rare bone anomaly is related to prenatal factors arising during the early phase of foetal development which prevent the laying down of certain parts of the osseous system.The cranial vault, the vertebral arches, and the pelvic and shoulder girdles may likewise manifest serious structural deficiencies.Short references to phocomelia have been made by Church and Peterson (1911( ), Aschoff (1928)), and Kaufmann (1929), but the most descriptive record, with