GPR48 Regulates Epithelial Cell Proliferation and Migration by Activating EGFR during Eyelid Development

Abstract

Inactivation of GPR48 induces the EOB phenotype by reducing epithelial cell proliferation and migration, indicating that GPR48 plays an essential role in eyelid development. Furthermore, GPR48 contributes to eyelid development through the regulation of the EGFR signaling pathway.