Inhibition of human ether-a-go-go-related gene potassium channels by a1-adrenoceptor antagonists prazosin, doxazosin, and terazosin

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Owen P. Hamill, Alain Marty, Erwin Neher et al. · Pflügers Archiv - European Journal of Physiology · 1981 · 18.5K citations

Electrical Engineering, Engineering, Cell-free Membrane Patches +7

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +10

Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group · JAMA · 2000 · 1.5K citations

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

Geoffrey W. Abbott, Federico Sesti, Igor Splawski et al. · Cell · 1999 · 1.3K citations · Full text

A family of potassium channel genes related to eag in Drosophila and mammals.

Jeffrey W. Warmke, Barry Ganetzky · Proceedings of the National Academy of Sciences · 1994 · 977 citations

Genetics, Molecular Genetics, Cellular Physiology +21