Clinical Significance of Immunohistochemical Expression of Hypoxia-Inducible Factor–1α as a Prognostic Marker in Rectal Adenocarcinoma

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

Jo A. Forsythe, Bing‐Hua Jiang, Narayan V. Iyer et al. · Molecular and Cellular Biology · 1996 · 4K citations · Full text

Life Sciences, Genetics, Molecular Biology +15

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza, G.L. Wang · Molecular and Cellular Biology · 1992 · 2.4K citations · Full text

Medicine, Genetics, Molecular Biology +17

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

Medicine, Cancer Biology, Oncology +14

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

Eric Huang, Zoltàn Arany, David M. Livingston et al. · Journal of Biological Chemistry · 1996 · 1.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16