Concepedia

Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication

Daekyu Choi, Jeongoh Han, Youna Lee, Jungyun Choi, Song-Yi Han, Sungchae Hong, Hyunchu Jeon, Young Mi Kim, Yunjin Jung

The Journal of Nutritional Biochemistry · 2009 · 36 citations · 46 references

DOI

Concepts

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46

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

Richard K. Bruick, Steven L. McKnight · Science · 2001 · 2.5K citations

, , +16

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Nancy C. Andrews, Douglas V. Faller · Nucleic Acids Research · 1991 · 2.3K citations · Full text

, , +11