Concepedia

Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages

Takashi Tanaka, Shizuo Akira, Kanji Yoshida, Masanori Umemoto, Yoshihiro Yoneda, Naoki Shirafuji, Hiroshi Fujiwara, Sachiko Suematsu, Nobuaki Yoshida, Tadamitsu Kishimoto

Cell · 1995 · 531 citations · 42 references

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42

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

Aihao Ding, Carl Nathan, Dennis J. Stuehr · The Journal of Immunology · 1988 · 2.8K citations · Full text

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Klaus Pfeffer, T. Matsuyama, Thomas M. Kündig et al. · Cell · 1993 · 1.7K citations

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

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Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

Z Cao, Robert M. Umek, Steven L. McKnight · Genes & Development · 1991 · 1.7K citations · Full text

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