One‐Pot Synthesis of (±)‐Crispine A and Its C‐Ring‐Substituted Analogs

Abstract

Abstract A straightforward access to crispine A and C‐ring‐substituted analogs by 1,4‐addition of a deprotonated α‐amino nitrile to α,β‐unsaturated carbonyl compounds is described. If the reduction step is omitted, substituted 5,6‐dihydropyrrolo[2,1‐ a ]isoquinolines can be obtained. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)