Concepedia

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

Matthew I. Wahl, Thomas O. Daniel, Graham Carpenter

Science · 1988 · 321 citations · 19 references

DOI

Concepts

Abstract

A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.

References

19

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

Hiroshi Ushiro, Stanley Cohen · Journal of Biological Chemistry · 1980 · 1.2K citations · Full text

, , +12

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

Stanley Cohen, G Carpenter, Lloyd E. King · Journal of Biological Chemistry · 1980 · 854 citations · Full text

, , +15

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

William S. Chen, Cheri S. Lazar, Martin Poenie et al. · Nature · 1987 · 600 citations

, , +14

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

G Carpenter, Lloyd E. King, Stanley Cohen · Journal of Biological Chemistry · 1979 · 529 citations · Full text

, , +10

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

Y. Sugimoto, Malcolm Whitman, Lewis C. Cantley et al. · Proceedings of the National Academy of Sciences · 1984 · 476 citations · Full text

, , +11