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Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells
321
Citations
19
References
1988
Year
Epidermal Growth FactorPhospholipase C ActivityPathologyCell GrowthCellular PhysiologyTumor BiologyEgf TreatmentSignaling PathwayReceptor Tyrosine KinaseCell SignalingTenfold IncreasePharmacologyCell BiologyTumor MicroenvironmentProtein PhosphorylationSignal TransductionPip2 HydrolysisCellular BiochemistryMedicineCancer GrowthAntiphosphotyrosine RecoveryExtracellular Matrix
A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.
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