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Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

γ-Glutamyl MetaboliteAldo-keto ReductaseAldehyde DehydrogenaseBiochemistryStoichiometric InhibitionMedicineMetabolomic ProfilingMammalian Dihydrofolate ReductaseMetabolomicsMetabolismPharmacologyRedox BiologyMetabolic InteractionsOxidative Stress