Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Manuel Serrano, Gregory J. Hannon, David Beach · Nature · 1993 · 3.7K citations

Life Sciences, Cell Biology, Molecular Biology +17

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

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Life Sciences, Genetics, Molecular Genetics +17

Mutations in the p53 gene occur in diverse human tumour types

Janice Nigro, Suzanne J. Baker, Antonette C. Preisinger et al. · Nature · 1989 · 2.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

Medicine, Genetics, Molecular Biology +17

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

Tsutomu Nobori, Kaoru Miura, David Wu et al. · Nature · 1994 · 1.8K citations

Medicine, Molecular Genetics, Oncology +14